complex cyclosome apc c inhibitor protame Search Results


anaphase-promoting complex/cyclosome (apc/c)  (The Company of Biologists)
90
The Company of Biologists anaphase-promoting complex/cyclosome (apc/c)
Anaphase Promoting Complex/Cyclosome (Apc/C), supplied by The Company of Biologists, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anaphase-promoting complex/cyclosome (apc/c)  (Genentech inc)
90
Genentech inc anaphase-promoting complex/cyclosome (apc/c)
Anaphase Promoting Complex/Cyclosome (Apc/C), supplied by Genentech inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anaphase-promoting complex/cyclosome (apc/c)  (Pfleger GmbH)
90
Pfleger GmbH anaphase-promoting complex/cyclosome (apc/c)
Anaphase Promoting Complex/Cyclosome (Apc/C), supplied by Pfleger GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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cdc20 protein  (Wieser GmbH)
90
Wieser GmbH cdc20 protein
Cdc20 Protein, supplied by Wieser GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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apc/c-cdh1  (Pfleger GmbH)
90
Pfleger GmbH apc/c-cdh1
Apc/C Cdh1, supplied by Pfleger GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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apc/c  (Wieser GmbH)
90
Wieser GmbH apc/c
Apc/C, supplied by Wieser GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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apc/c  (Johns Hopkins HealthCare)
90
Johns Hopkins HealthCare apc/c
Apc/C, supplied by Johns Hopkins HealthCare, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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apc/c - by Bioz Stars, 2026-10
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protame  (Merck KGaA)
90
Merck KGaA protame
ARV7 mediates DTX sensitivity through the mitotic slippage pathway. A , chemical structure of the <t>APC/C</t> inhibitor <t>proTAME.</t> B , virus-infected PC-3 cells were cotreated with 50 μM proTAME and different concentrations of DTX for 72 h, and then cells were harvested for MTT assay. C , PC-3 cells were treated with DTX arrest for 18 h, then medium was refreshed to release the cells in the presence of 100 μg/ml CHX (DMSO/50 μM proTAME was kept in the medium for the entire experiments), after indicated time points, cells were harvested for IB. D , virus-infected PC-3 cells (vector or shUBE2C) were transfected with indicated plasmid for 24 h and reseeded for IB and MTT assay after DTX treatment. E , virus-infected PC-3 cells (vector or shUBE2C) were transfected with EGFP-ARV7 plasmid and subjected to DTX arrest and release treatment before harvesting for IB. F , ARV7-depleted 22RV-1 cells were transfected with vector control or UBE2C for 24 h and then treated with or without indicated concentration of DTX for another 24 h before IB analysis. G , proposed model for the study, ARV7 status affects the function of the SAC, subsequently regulating the cell fate after DTX treatment.
Protame, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/complex+cyclosome+apc+c+inhibitor+protame/protame/pmc07948795-159-1-7
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apc/c inhibitor protame  (Merck KGaA)
90
Merck KGaA apc/c inhibitor protame
ARV7 mediates DTX sensitivity through the mitotic slippage pathway. A , chemical structure of the <t>APC/C</t> inhibitor <t>proTAME.</t> B , virus-infected PC-3 cells were cotreated with 50 μM proTAME and different concentrations of DTX for 72 h, and then cells were harvested for MTT assay. C , PC-3 cells were treated with DTX arrest for 18 h, then medium was refreshed to release the cells in the presence of 100 μg/ml CHX (DMSO/50 μM proTAME was kept in the medium for the entire experiments), after indicated time points, cells were harvested for IB. D , virus-infected PC-3 cells (vector or shUBE2C) were transfected with indicated plasmid for 24 h and reseeded for IB and MTT assay after DTX treatment. E , virus-infected PC-3 cells (vector or shUBE2C) were transfected with EGFP-ARV7 plasmid and subjected to DTX arrest and release treatment before harvesting for IB. F , ARV7-depleted 22RV-1 cells were transfected with vector control or UBE2C for 24 h and then treated with or without indicated concentration of DTX for another 24 h before IB analysis. G , proposed model for the study, ARV7 status affects the function of the SAC, subsequently regulating the cell fate after DTX treatment.
Apc/C Inhibitor Protame, supplied by Merck KGaA, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/complex+cyclosome+apc+c+inhibitor+protame/apc+c+inhibitor+protame/10__1016_slash_j__jbc__2021__100276-151-1-7
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apc/c inhibitor protame - by Bioz Stars, 2026-10
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mad2l2 protein  (Pfleger GmbH)
90
Pfleger GmbH mad2l2 protein
ARV7 mediates DTX sensitivity through the mitotic slippage pathway. A , chemical structure of the <t>APC/C</t> inhibitor <t>proTAME.</t> B , virus-infected PC-3 cells were cotreated with 50 μM proTAME and different concentrations of DTX for 72 h, and then cells were harvested for MTT assay. C , PC-3 cells were treated with DTX arrest for 18 h, then medium was refreshed to release the cells in the presence of 100 μg/ml CHX (DMSO/50 μM proTAME was kept in the medium for the entire experiments), after indicated time points, cells were harvested for IB. D , virus-infected PC-3 cells (vector or shUBE2C) were transfected with indicated plasmid for 24 h and reseeded for IB and MTT assay after DTX treatment. E , virus-infected PC-3 cells (vector or shUBE2C) were transfected with EGFP-ARV7 plasmid and subjected to DTX arrest and release treatment before harvesting for IB. F , ARV7-depleted 22RV-1 cells were transfected with vector control or UBE2C for 24 h and then treated with or without indicated concentration of DTX for another 24 h before IB analysis. G , proposed model for the study, ARV7 status affects the function of the SAC, subsequently regulating the cell fate after DTX treatment.
Mad2l2 Protein, supplied by Pfleger GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/complex+cyclosome+apc+c+inhibitor+protame/mad2l2+protein/pmc03020106-26-23-39
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cyclin b/cdk1 (promega, madison, wi)  (Promega)
90
Promega cyclin b/cdk1 (promega, madison, wi)
ARV7 mediates DTX sensitivity through the mitotic slippage pathway. A , chemical structure of the <t>APC/C</t> inhibitor <t>proTAME.</t> B , virus-infected PC-3 cells were cotreated with 50 μM proTAME and different concentrations of DTX for 72 h, and then cells were harvested for MTT assay. C , PC-3 cells were treated with DTX arrest for 18 h, then medium was refreshed to release the cells in the presence of 100 μg/ml CHX (DMSO/50 μM proTAME was kept in the medium for the entire experiments), after indicated time points, cells were harvested for IB. D , virus-infected PC-3 cells (vector or shUBE2C) were transfected with indicated plasmid for 24 h and reseeded for IB and MTT assay after DTX treatment. E , virus-infected PC-3 cells (vector or shUBE2C) were transfected with EGFP-ARV7 plasmid and subjected to DTX arrest and release treatment before harvesting for IB. F , ARV7-depleted 22RV-1 cells were transfected with vector control or UBE2C for 24 h and then treated with or without indicated concentration of DTX for another 24 h before IB analysis. G , proposed model for the study, ARV7 status affects the function of the SAC, subsequently regulating the cell fate after DTX treatment.
Cyclin B/Cdk1 (Promega, Madison, Wi), supplied by Promega, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/complex+cyclosome+apc+c+inhibitor+protame/cdk2+cyclin+a2+kinase+enzyme+system/pm20089842-65-2-7
Average 90 stars, based on 1 article reviews
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apc/c substrate cdc20  (Pfleger GmbH)
90
Pfleger GmbH apc/c substrate cdc20
ARV7 mediates DTX sensitivity through the mitotic slippage pathway. A , chemical structure of the <t>APC/C</t> inhibitor <t>proTAME.</t> B , virus-infected PC-3 cells were cotreated with 50 μM proTAME and different concentrations of DTX for 72 h, and then cells were harvested for MTT assay. C , PC-3 cells were treated with DTX arrest for 18 h, then medium was refreshed to release the cells in the presence of 100 μg/ml CHX (DMSO/50 μM proTAME was kept in the medium for the entire experiments), after indicated time points, cells were harvested for IB. D , virus-infected PC-3 cells (vector or shUBE2C) were transfected with indicated plasmid for 24 h and reseeded for IB and MTT assay after DTX treatment. E , virus-infected PC-3 cells (vector or shUBE2C) were transfected with EGFP-ARV7 plasmid and subjected to DTX arrest and release treatment before harvesting for IB. F , ARV7-depleted 22RV-1 cells were transfected with vector control or UBE2C for 24 h and then treated with or without indicated concentration of DTX for another 24 h before IB analysis. G , proposed model for the study, ARV7 status affects the function of the SAC, subsequently regulating the cell fate after DTX treatment.
Apc/C Substrate Cdc20, supplied by Pfleger GmbH, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/complex+cyclosome+apc+c+inhibitor+protame/cdc20+protein/pmc01770901-239-5-8
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apc/c substrate cdc20 - by Bioz Stars, 2026-10
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Image Search Results


ARV7 mediates DTX sensitivity through the mitotic slippage pathway. A , chemical structure of the APC/C inhibitor proTAME. B , virus-infected PC-3 cells were cotreated with 50 μM proTAME and different concentrations of DTX for 72 h, and then cells were harvested for MTT assay. C , PC-3 cells were treated with DTX arrest for 18 h, then medium was refreshed to release the cells in the presence of 100 μg/ml CHX (DMSO/50 μM proTAME was kept in the medium for the entire experiments), after indicated time points, cells were harvested for IB. D , virus-infected PC-3 cells (vector or shUBE2C) were transfected with indicated plasmid for 24 h and reseeded for IB and MTT assay after DTX treatment. E , virus-infected PC-3 cells (vector or shUBE2C) were transfected with EGFP-ARV7 plasmid and subjected to DTX arrest and release treatment before harvesting for IB. F , ARV7-depleted 22RV-1 cells were transfected with vector control or UBE2C for 24 h and then treated with or without indicated concentration of DTX for another 24 h before IB analysis. G , proposed model for the study, ARV7 status affects the function of the SAC, subsequently regulating the cell fate after DTX treatment.

Journal: The Journal of Biological Chemistry

Article Title: Androgen receptor splicing variant 7 (ARV7) inhibits docetaxel sensitivity by inactivating the spindle assembly checkpoint

doi: 10.1016/j.jbc.2021.100276

Figure Lengend Snippet: ARV7 mediates DTX sensitivity through the mitotic slippage pathway. A , chemical structure of the APC/C inhibitor proTAME. B , virus-infected PC-3 cells were cotreated with 50 μM proTAME and different concentrations of DTX for 72 h, and then cells were harvested for MTT assay. C , PC-3 cells were treated with DTX arrest for 18 h, then medium was refreshed to release the cells in the presence of 100 μg/ml CHX (DMSO/50 μM proTAME was kept in the medium for the entire experiments), after indicated time points, cells were harvested for IB. D , virus-infected PC-3 cells (vector or shUBE2C) were transfected with indicated plasmid for 24 h and reseeded for IB and MTT assay after DTX treatment. E , virus-infected PC-3 cells (vector or shUBE2C) were transfected with EGFP-ARV7 plasmid and subjected to DTX arrest and release treatment before harvesting for IB. F , ARV7-depleted 22RV-1 cells were transfected with vector control or UBE2C for 24 h and then treated with or without indicated concentration of DTX for another 24 h before IB analysis. G , proposed model for the study, ARV7 status affects the function of the SAC, subsequently regulating the cell fate after DTX treatment.

Article Snippet: The APC/C inhibitor proTAME was purchased from Merck Millipore and dissolved in DMSO.

Techniques: Infection, MTT Assay, Plasmid Preparation, Transfection, Concentration Assay

Inhibiting mitotic slippage enhances the toxicity of DTX in ARV7-expressing PCa cells. A , Upper panel , 22RV-1 cells were subjected to different concentration of proTAME for 72 h and harvested for MTT assay, ∗ p < 0.05 compared with the DMSO control. Lower panel , 22RV-1 cells were treated with different concentration of DTX alone or in combination with 50 μM proTAME for 72 h and then harvested for MTT assay. B , 22RV-1 cells were treated with proTAME, DTX, or proTAME plus DTX for 24 h and then subjected to IB. C , Upper panel , virus-infected PC-3 cells were subjected to different drug treatments as indicated and harvested for MTT assay. Lower panel, virus-infected PC-3 cells were treated with proTAME, DTX, or proTAME plus DTX for 24 h and then subjected to IB. D , virus-infected PC-3 cells were seeded in 6-well plate (1000 cells per well) treated with (DMSO as control) 0.5 nM DTX, 10 μM proTAME, or both for 15 days, medium was refreshed every 2 days, and then cells were fixed and stained, followed by quantification of the clones. E , IC50 values of DTX and proTAME in 22RV-1 and ARV7-expressing PC-3 cells.

Journal: The Journal of Biological Chemistry

Article Title: Androgen receptor splicing variant 7 (ARV7) inhibits docetaxel sensitivity by inactivating the spindle assembly checkpoint

doi: 10.1016/j.jbc.2021.100276

Figure Lengend Snippet: Inhibiting mitotic slippage enhances the toxicity of DTX in ARV7-expressing PCa cells. A , Upper panel , 22RV-1 cells were subjected to different concentration of proTAME for 72 h and harvested for MTT assay, ∗ p < 0.05 compared with the DMSO control. Lower panel , 22RV-1 cells were treated with different concentration of DTX alone or in combination with 50 μM proTAME for 72 h and then harvested for MTT assay. B , 22RV-1 cells were treated with proTAME, DTX, or proTAME plus DTX for 24 h and then subjected to IB. C , Upper panel , virus-infected PC-3 cells were subjected to different drug treatments as indicated and harvested for MTT assay. Lower panel, virus-infected PC-3 cells were treated with proTAME, DTX, or proTAME plus DTX for 24 h and then subjected to IB. D , virus-infected PC-3 cells were seeded in 6-well plate (1000 cells per well) treated with (DMSO as control) 0.5 nM DTX, 10 μM proTAME, or both for 15 days, medium was refreshed every 2 days, and then cells were fixed and stained, followed by quantification of the clones. E , IC50 values of DTX and proTAME in 22RV-1 and ARV7-expressing PC-3 cells.

Article Snippet: The APC/C inhibitor proTAME was purchased from Merck Millipore and dissolved in DMSO.

Techniques: Expressing, Concentration Assay, MTT Assay, Infection, Staining, Clone Assay